Publications and preprints
Marshall-Burghardt S., Migueles-Ramírez RA., Lin Q., El Baba N., Saada R., Umar M., Mavalwala K., Hayer A. Excitable Rho dynamics control cell shape and motility by sequentially activating ERM proteins and actomyosin contractility. Science Advances 10(36) (2024). [Pubmed] [Journal]. Related [bioRxiv preprint] [preLights]
Migueles-Ramírez R.A., Cambi A., Hayer A., Wiseman PW., van den Dries K. Quantifying superimposed protein flow dynamics in live cells using spatial filtering and spatiotemporal image correlation spectroscopy. Journal of Microscopy (2024). [Pubmed] [Journal]
Garbett D., Bisaria A., Yang C., McCarthy DG., Hayer A., Moerner WE., Svitkina TM., Meyer T. T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration. Nature Communications 11(1):4818 (2020). [Pubmed] [Journal]
Bisaria A., Hayer A., Garbett D., Cohen D., Meyer T. Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration. Science 368 (6496), 1205-1210 (2020). [Pubmed] [Journal]
Ponroy Bally B., Farmer WT., Jones EV., Jessa S., Kacerovsky J., Mayran A., Peng H., Lefebvre J., Drouin J., Hayer A., Ernst C., Murai KK. Human iPSC-Derived Down Syndrome Astrocytes Display Genome-Wide Perturbations in Gene Expression, an Altered Adhesion Profile, and Increased Cellular Dynamics. Human Molecular Genetics 29 (5), 785-802 (2020). [Pubmed] [Journal]
Gan L., Seki A., Shen K., Iyer H., Han K., Hayer A., Wollman R., Ge X., Lin JR., Dey G., Talbot WS., Meyer T. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Nature Cell Biology 21(5),614-626 (2019). [Pubmed] [Journal]
Hayer A., Shao L., Chung M., Joubert LM., Yang HW, Tsai FC., Bisaria A., Betzig E., Meyer T. Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells. Nature Cell Biology 18(12), 1311-1323 (2016). [Pubmed] [Journal] [Issue Highlight in Nat Cell Biol] [Highlight in Nat Rev Mol Cell Biol] [F1000] [Addgene]
Malmersjö S., Di Palma S., Diao J., Lai Y., Pfuetzner RA., Wang AL., McMahon MA., Hayer A., Porteus M., Bodenmiller B., Brunger AT., Meyer T. Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion. EMBO Journal 35(16), 1810-1821 (2016). [Pubmed] [Journal]
Rengarajan, M., Hayer A., and Theriot JA. Endothelial Cells Use a Formin-Dependent Phagocytosis-Like Process to Internalize the Bacterium Listeria monocytogenes. PLoS Pathogens 12(5), e1005603 (2016). [Pubmed] [Journal] [F1000]
Tsai FC., Seki A., Yang HW. , Hayer A., Carrasco S., Malmersjö S., and Meyer T. A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration. Nature Cell Biology 16, 133-144 (2014). [Pubmed] [Journal] [F1000]
Ritz D., Vuk M., Kirchner P., Bug M., Schütz S., Hayer A., Bremer S., Lusk C., Baloh RH., Lee H., Glatter T., Gstaiger M., Aebersold R., Weihl CC., and Meyer H. Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations. Nature Cell Biology 13, 1116-1123 (2011). [Pubmed] [Journal] [F1000]
Engel S., Heger T., Mancini R., Herzog F., Kartenbeck J., Hayer A., and Helenius A. Role of endosomes in simian virus 40 entry and infection. Journal of Virology 85, 4198–4211 (2011). [Pubmed] [Journal] [F1000]
Geiger R., Gautschi M., Thor F., Hayer A., and Helenius A. Folding, quality control, and secretion of pancreatic ribonuclease in live cells. The Journal of Biological Chemistry 286, 5813–5822 (2011). [Pubmed] [Journal]
Hayer A., Stoeber M., Ritz D., Engel S., Meyer HH., and Helenius A. Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradation. The Journal of Cell Biology 191, 615–629 (2010). [Pubmed] [Journal] [Issue Highlight in JCB] [F1000] [Addgene]
Hayer A., and Meyer T. High-content imaging. Nature Biotechnology 28, 424–425 (2010). [Pubmed] [Journal]
Hayer A., Stoeber M., Bissig C., and Helenius A. Biogenesis of caveolae: stepwise assembly of large caveolin and cavin complexes. Traffic 11, 361–382 (2010). [Pubmed] [Journal] [F1000] [Addgene]
Sbalzarini IF., Hayer A., Helenius A., and Koumoutsakos P. Simulations of (an)isotropic diffusion on curved biological surfaces. Biophysical Journal 90, 878–885 (2006). [Pubmed] [Journal] [F1000]
Tagawa A., Mezzacasa A., Hayer A., Longatti A., Pelkmans L., and Helenius A. Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters. The Journal of Cell Biology 170, 769–779 (2005). [Pubmed] [Journal] [F1000] [Addgene]
Hayer A., and Bhalla U.S. Molecular switches at the synapse emerge from receptor and kinase traffic. PLoS Computational Biology1, 137–154 (2005). [Pubmed] [Journal]
